High urinary concentrations of parabens and bisphenol A in very low birth weight infants

Very low birth weight infants (VLBW; < 1500 g) are treated with pharmaceuticals and medical equipment containing parabens bisphenol A (BPA). Parabens used in pharmaceuticals, whereas BPA where concentrations rarely reported hospitalised VLBW infants. We measured urinary of hypothesised high increasing born at lower gestational ages (GAs), among bronchopulmonary dysplasia (BPD) late-onset septicaemia (LOS) due to higher exposure from equipment. Urinary samples were collected during the first (n = 38) fifth 36) week life. Methylparaben, ethylparaben, propylparaben, butylparaben, using ultra high-performance liquid chromatography coupled tandem mass spectrometry. had very compared term older children. The ? paraben concentration was than detected previous studies on premature Lower GA associated BPA. Infants before 28 weeks propylparaben (38.6 vs. 9.05 ng/mL, p 0.007), butylparaben (0.28 0.09 0.05) (15.1 6.02 0.02) after GA. LOS BPD without (LOS: 14.2 6.77 0.07; BPD: 18.6 7.62 0.05).